Another case-control study published in October pointed out increased risk of stent thrombosis for patients taking Plavix with variations in a gene called CYP2C19. Patients with adverse events were two times more likely to have half of the gene be non-functional. Called intermediate metabolizers, this represents about one-third of patients. Patients with no CYP2C19 function, called poor metabolizers, were seven times more likely to have an adverse event. About 2-4% of Caucasians, 10% of Africans, and 20% of Asians are poor metabolizers. If you or a loved one is taking Plavix, ask about DNA Drug Sensitivity Testing.See more at theheart.org/article/1300023.do
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DNA consists of two long polymers of simple units called nucleotides, with backbones made of sugars and phosphate groups joined by ester bonds. These two strands run in opposite directions to each other and are therefore anti-parallel, one backbone being 3' (three prime) and the other 5' (five prime). This refers to the direction the 3rd and 5th carbon on the sugar molecule is facing. Attached to each sugar is one of four types of molecules called nucleobases (informally, bases). It is the sequence of these four nucleobases along the backbone that encodes information. This information is read using the genetic code, which specifies the sequence of the amino acids within proteins. The code is read by copying stretches of DNA into the related nucleic acid RNA in a process called transcription.
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